Deoxysugar Synthesis. III. Removal of Vicinal Mesyloxy Groups with Naphthalene-Sodium
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概要
- 論文の詳細を見る
Naphthalene-sodium reaction of 3,4-dimesylates of N-protected 2,6-diamino-2,6-dideoxy-α-D-glycosides (1a, 1b) resulted in a good yield of 3-eno compounds (2a, 2b). Application of this anion-radical reaction to butirosin 3', 4'-dimesylate (3) gave 3', 4'-dideoxy-3'-one butirosin A (4a) which shows a broad inhibitory activity against bacteria which are both sensitive and resistant to butirosin. Kanamycin 3', 4'-dimesylate (5a) also analogously gave a 3'-eno derivative (6).
- 社団法人日本薬学会の論文
- 1977-08-25
著者
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大木 英二
Central Research Laboratories, Sankyo Co., Ltd.
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林 輝雄
Chemical Research Laboratories Sankyo Co. Ltd.
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佐伯 博道
Central Research Laboratories, Sankyo Co., Ltd.
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大木 英二
Research Laboratory Zenyaku Kogyo Co. Ltd.
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大木 英二
Central Research Laboratories Sankyo Co. Ltd.
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林 輝雄
Central Research Laboratories, Sankyo Co., Ltd.
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武田 憲子
Central Research Laboratories, Sankyo Co., Ltd.
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武田 憲子
Medical Chemistry Research Laboratories Sankyo Co. Ltd.
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佐伯 博道
Central Research Laboratories Sankyo Co. Ltd.
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