Studies on Bi-heterocyclic Compounds. II. : 5-Substituted Thiazolones
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概要
- 論文の詳細を見る
Reactions of-methyl-2(3H)-thiazolones (5) with various N-alkoxycarbonyl pyridinium salts (6a-f) led to (N-alkoxycarbonyl dihydropyridyl)thiazolones (7a-f), oxidation of which yielded a new class of 5-pyridylthiazolones (8a-f). These reactions were applied to the synthesis of other azaarylthiazolones. Some of these azaarylthiazolones, particualrly 5-(4-pyridyl)thiazolones (8b, c) and 5-(4-quinolyl)thiazolones (14a, b), showed positive inotropic activity with little chronotropic effect on guinea pig left atria.
- 社団法人日本薬学会の論文
- 1990-01-25
著者
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高瀬 宗章
Research Laboratory of Zen-Yaku Kogyo Co., Ltd.
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大木 英二
Research Laboratory Zenyaku Kogyo Co. Ltd.
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山崎 宏亮
Research Laboratory, Zenyaku Kogyo Co. Ltd.,
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原田 秀範
Research Laboratory, Zenyaku Kogyo Co. Ltd.,
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松崎 憲一
Research Laboratory, Zenyaku Kogyo Co. Ltd.,
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吉岡 君友
Research Laboratory, Zenyaku Kogyo Co., Ltd.,
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吉岡 君友
Research Laboratory Zenyaku Kogyo Co. Ltd.
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高瀬 宗章
Research Laboratory Zenyaku Kogyo Co. Ltd.
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山崎 宏亮
Research Laboratory Zenyaku Kogyo Co. Ltd.
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原田 秀範
Research Laboratory Zenyaku Kogyo Co. Ltd.
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松崎 憲一
Research Laboratory Zenyaku Kogyo Co. Ltd.
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高瀬 宗章
Research Laboratory, Zenyaku Kogyo Co., Ltd.,
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