Antiallergic Substance from Asarum sagittarioides and Synthesis of Some Analogues(Pharmacognosy,Chemical)

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概要

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• The MeOH extract of Asarum sagittarioides(Aristolochiaceae) showed antihistarninic activity. N-Isobutyl-3,4-methylenedioxybenzamide (1) was isolated as the active principle, and this compound was proved to be an antiallergic substance by pharmacological studies. Furthermore, in order to investigate the structure-activity relationships, some analogues of 1 were synthesized, and compounds 4 and 5 were found to show more potent activity than 1.

• 社団法人日本薬学会の論文
• 1987-06-25

著者

• 成田 利晴

  Research Laboratory Zenyaku Kogyo Co. Ltd.

• 寺田 澄男

  Central Research Laboratory, Zenyaku Kogyo Co., Ltd.

• 本宮 卓

  Central Research Laboratory, Zenyaku Kogyo Co., Ltd.

• 吉岡 君友

  Central Research Laboratory, Zenyaku Kogyo Co., Ltd.

• 成田 利晴

  Central Research Laboratory, Zenyaku Kogyo Co., Ltd.

• 安井 聰祐

  Central Research Laboratory, Zenyaku Kogyo Co., Ltd.

• 高瀬 宗章

  Central Research Laboratory, Zenyaku Kogyo Co., Ltd.

• 吉岡 君友

  Research Laboratory, Zenyaku Kogyo Co., Ltd.,

• 本宮 卓

  Central Research Laboratory Zenyaku Kogyo Co. Ltd.

• 吉岡 君友

  Research Laboratory Zenyaku Kogyo Co. Ltd.

• 安井 聰祐

  Central Research Laboratory Zenyaku Kogyo Co. Ltd.

• 寺田 澄男

  Central Research Laboratory Zenyaku Kogyo Co. Ltd.

• 高瀬 宗章

  Research Laboratory Zenyaku Kogyo Co. Ltd.

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