Dihydrothiazine Ring-Opening Reactions in 2-Alkoxycephalosporin Compounds
スポンサーリンク
概要
- 論文の詳細を見る
2-Alkoxy-3-cephem-1-oxides 1b-c were found to be thermally unstable and easily converted into isothiazolones 5a-f, β-lactam 12 and thiazole 14 according to reaction conditions. Further, 2-alkoxy-3-cephem 4a-b was treated with tert-butyl hypochlorite to give azetidinone-oxazoline acetals 18a-b. Formation of these rearrangement products was interpreted via the sulfenic acid intermediate 6 or 17.
- 社団法人日本薬学会の論文
- 1977-08-25
著者
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大木 英二
Central Research Laboratories, Sankyo Co., Ltd.
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老田 貞夫
Central Research Laboratories, Sankyo Co., Ltd.
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吉田 明
Central Research Laboratories, Sankyo Co., Ltd.
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吉田 明
Chemical Research Laboratories Sankyo Co. Ltd.
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老田 貞夫
Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd.,
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大木 英二
Research Laboratory Zenyaku Kogyo Co. Ltd.
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大木 英二
Central Research Laboratories Sankyo Co. Ltd.
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老田 貞夫
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
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