2-(Alkylthio) penem-3-carboxylic Acids. V. Synthesis and Antibacterial Activities of "1-Thiathienamycin"and Related Compounds

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概要

• 論文の詳細を見る

• The synthesis of optically active "1-thiathienamycin"13a and other (hydroxyethyl)-penemcarboxylic acids from the 8R and 8S azetidinones 3 and 4 via an intramolecular Wittig reaction of the trithiocarbonatephosphoranes 7 is described. Trans and cis penem esters 8 and 9 were found to form an equilibrium mixture on heating. The antibacterial activities of these penemcarboxylic acids are discussed.

• 社団法人日本薬学会の論文
• 1981-11-25

著者

• 大木 英二

  Central Research Laboratories, Sankyo Co., Ltd.

• 老田 貞夫

  Central Research Laboratories, Sankyo Co., Ltd.

• 吉田 明

  Central Research Laboratories, Sankyo Co., Ltd.

• 吉田 明

  Chemical Research Laboratories Sankyo Co. Ltd.

• 老田 貞夫

  Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd.,

• 林 輝雄

  Chemical Research Laboratories Sankyo Co. Ltd.

• 菅原 眞一

  Central Research Laboratories, Sankyo Co., Ltd.

• 大木 英二

  Research Laboratory Zenyaku Kogyo Co. Ltd.

• 大木 英二

  Central Research Laboratories Sankyo Co. Ltd.

• 林 輝雄

  Central Research Laboratories, Sankyo Co., Ltd.

• 武田 憲子

  Central Research Laboratories, Sankyo Co., Ltd.

• 武田 憲子

  Medical Chemistry Research Laboratories Sankyo Co. Ltd.

• 老田 貞夫

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

• 菅原 眞一

  Central Research Laboratories Sankyo Co. Ltd.

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