β-Lactam Antifungals. II. Enantiocontrolled Synthesis of (2R, 5S)-2-Hydroxymethyl-1-carbapenam, the Carba-Analog of a Clavam Antifungal
スポンサーリンク
概要
- 論文の詳細を見る
(2R, 5S)-2-Hydroxymethyl-1-carbapenam (3), the carba-analog of an antifungal β-lactam (2R, 5S)-2-(hydroxymethyl)clavam (1), was synthesized in an enantiocontrolled manner, starting from the coupling reaction of an optically active phthalimido-acetate (3S, 4S)-4 and an allylsilane 7,followed by removal of the phthalimido group that was crucial for asymmetric induction. Hydroboration, protecting-group interconversion, and cyclization gave 3 stereoselectively.
- 公益社団法人日本薬学会の論文
- 1991-11-25
著者
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畠 忠
Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd.,
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鴻巣 俊之
Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd.,
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老田 貞夫
Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd.,
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古川 洋司
Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd.,
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古川 洋司
Analytical And Metabolic Research Laboratories Sankyo Co. Ltd.
-
畠 忠
Analytical And Metabolic Research Laboratories Sankyo Co. Ltd.
-
老田 貞夫
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
-
鴻巣 俊之
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
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鴻巣 俊之
Medicinal Chemistry Res. Laboratories Ii Daiichi Sankyo Co. Ltd.
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