NEW SYNTHESIS OF PENEMS VIA A REDUCTIVE CYCLIZATION REACTION OF OXALIMIDES WITH TRIALKYL PHOSPHITE

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概要

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• Treatment of the oxalimide 5 with triethyl phosphite formed the penem 3 and the triethoxyphosphonium ylide 7,presumably via the common carbene intermediate 10. Prolonged heating of 7 afforded 3 and its C-5 epimer. Similar reaction of the oxalimide 13 with trimethyl phosphite gave only the ylide 14,which was further heated to cyclize to the penem 15.

• 社団法人日本薬学会の論文
• 1983-02-25

著者

• 吉田 明

  Chemical Research Laboratories Sankyo Co. Ltd.

• 老田 貞夫

  Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd.,

• 林 輝雄

  Chemical Research Laboratories Sankyo Co. Ltd.

• 大木 英二

  Research Laboratory Zenyaku Kogyo Co. Ltd.

• 武田 憲子

  Chemical Research Laboratories, Sankyo Co., Ltd.

• 老田 貞夫

  Chemical Research Laboratories, Sankyo Co., Ltd.

• 大木 英二

  Chemical Research Laboratories, Sankyo Co., Ltd.

• 武田 憲子

  Medical Chemistry Research Laboratories Sankyo Co. Ltd.

• 老田 貞夫

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

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