Synthetic Study of Siccanin, an Antifungal Antibiotic. I. Synthesis of 3,5a-Dimethyl-1-hydroxy-5,5a, 6,7,8,8a-hexahydroxanthene

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概要

• 論文の詳細を見る

• Refering to the previous work, ^<2)> tetracyclic diol (3a) derived from siccanin (1), an antifungal antibiotic, was converted back into 1; and 3a was shown as an important synthetic intermediate for 1. On the other hand, as a preliminary study on synthesis of 1,cyclization of 1-methyl-2-(2,6-dihydroxy-4-methylbenzyl)cyclohexanol (19 or 20) or 1-methylene-2-(2,6-dihydroxy-4-methylbenzyl)cyclohexane (21) was carried out, forming a hexahydroxanthene derivative (23) whose structure involves the B, C, and D rings of siccanin (1).

• 社団法人日本薬学会の論文
• 1972-12-25

著者

• 大木 英二

  Central Research Laboratories, Sankyo Co., Ltd.

• 老田 貞夫

  Central Research Laboratories, Sankyo Co., Ltd.

• 大橋 芳彦

  Central Research Laboratories, Sankyo Co., Ltd.

• 吉田 明

  Central Research Laboratories, Sankyo Co., Ltd.

• 吉田 明

  Chemical Research Laboratories Sankyo Co. Ltd.

• 大橋 芳彦

  Central Research Laboratories Sankyo Co. Ltd.

• 大木 英二

  Research Laboratory Zenyaku Kogyo Co. Ltd.

• 大木 英二

  Central Research Laboratories Sankyo Co. Ltd.

• 老田 貞夫

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

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