Syntheses of Highly Antibacterial 3-Vinylcephalosporin Derivatives

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概要

• 論文の詳細を見る

• 7-Acylamido-3-[2-(1-methyl-1H-tetrazol-5-yl) vinyl]-3-cephem-4-carboxylic acids including the 7-methoxy derivatives were prepared by two synthetic methods. The first method involves the reaction of the 3-bromomethylcephalosporin derivative (III) with 5-methylsulfinylemthyl-1-methyl-1H-tetrazole (IV) followed by thermal elimination leading to an olefinic compound (VI). An alternative olefin formation was carried out by utilizing the Wittig reaction of the 3-formylcephalosporin derivative (X). Among the 3-tetrazolylvinylcephalosporin derivatives, the mandelamido derivative (XVa) showed the best in vitro antibacterial activities against gram negative bacteria.

• 社団法人日本薬学会の論文
• 1978-06-25

著者

• 宮寺 哲男

  Central Research Laboratories, Sankyo Co., Ltd.

• 田中 輝夫

  Central Research Laboratories, Sankyo Co., Ltd.

• 田中 輝夫

  Central Research Laboratories Sankyo Co. Ltd.

• 渡辺 泰一郎

  Chemical Research Laboratories Sankyo Co. Ltd.

• 橋本 敏彦

  Central Research Laboratories Sankyo Co. Ltd.

• 渡辺 泰一郎

  Central Research Laboratories, Sankyo Co., Ltd.

• 宮寺 哲男

  Chemical Research Laboratories, Sankyo Co., Ltd.

• 川野 洋一

  Central Research Laboratories, Sankyo Co., Ltd.

• 長野 光男

  Central Research Laboratories, Sankyo Co., Ltd.

• 夏目 幸子

  Central Research Laboratories, Sankyo Co., Ltd.

• 菅原 真一

  Central Research Laboratories, Sankyo Co., Ltd.

• 川野 洋一

  Central Research Laboratories Sankyo Co. Ltd.

• 宮寺 哲男

  Chemical Research Laboratories Sankyo Co. Ltd.

• 菅原 真一

  Research Institute:sankyo Co. Ltd.

• 長野 光男

  Central Research Laboratories Sankyo Co. Ltd.

• 夏目 幸子

  Central Research Laboratories Sankyo Co. Ltd.

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