Studies on Chemotherapeutic Agents. II. Synthesis and Antibacterial Activity of 5-Substituted-5,8-dihydro-8-oxopyrido [2,3-b]-pyrazine-7-carboxylic Acids

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概要

• 論文の詳細を見る

• A series of 5-substituted-5,8-dihydro-8-oxopyrido [2,3-b] pyrazine-7-carboxylic acids were synthesized and evaluated as antibacterial agents. The most active compound in vitro against Escherichia coli and Staphylococcus aureus was 5-ethyl-3-(1-pyrrolidinyl)-5,8-dihydro-8-oxopyrido [2,3-b] pyrazine-7-carboxylic acid (XVIe). Structure-activity relationships are discussed.

• 社団法人日本薬学会の論文
• 1974-08-25

著者

• 中尾 英雄

  Central Research Laboratories, Sankyo Co., Ltd.

• 福島 正美

  Central Research Laboratories, Sankyo Co., Ltd.

• 福島 正美

  Central Research Laboratories Sankyo Co. Ltd.

• 菅原 真一

  Central Research Laboratories, Sankyo Co., Ltd.

• 柳沢 宏明

  Central Research Laboratories, Sankyo Co., Ltd.

• 柳沢 宏明

  Research Institute, Sankyo Co., Ltd.,

• 柳沢 宏明

  Research Institute Sankyo Co. Ltd.

• 中尾 英雄

  Central Research Laboratories Sankyo Co. Ltd.

• 菅原 真一

  Research Institute:sankyo Co. Ltd.

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