From Penicillin to Penem and Carbapenem. VII. : Synthesis and Antibacterial Activity of Penem Derivatives

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概要

• 論文の詳細を見る

• The azetidinone derivative (6), which has an (R)-hydroxyethyl substituent at the C-3 position, was prepared efficiently from 6-aminopenicillanic acid. From the dibromo seco derivative (10), compounds of the same type (16 and 17), but in dl-form, were obtained. Compounds 6 and 16 were reacted with various thiocarboxylic acids to obtain the penem derivatives (23a-n).The minimum inhibitory concentration values of these penems against various microorganisms were, determined, and the structure-activity relationship is discussed.

• 公益社団法人日本薬学会の論文
• 1986-03-25

著者

• 藤本 克巳

  Chemical Research Laboratories:sankyo Co. Ltd.

• 菅原 真一

  Research Institute:sankyo Co. Ltd.

• 平井 功一

  第一三共(株)

• 岩野 雄次

  Chemical Research Laboratories

• 平井 功一

  Chemical Research Laboratories

• 岩野 雄次

  Chemical Research Laboratories:sankyo Co. Ltd.

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