Synthesis of Oxapenam Derivatives by Silver Induced Cyclization

スポンサーリンク

概要

• 論文の詳細を見る

• The chloro-β-lactam derivatives (VII and XIIIa, b, c) were prepared from the readily available 4-acetoxy-2-azetidinone (III) in four steps. Silver triflate treatment of these chloro β-lactam derivatives in the presence of NaH gave the oxapenam derivatives (VIII and XIVa, b, c) in 3.5-11.6% yield after careful chromatography separation. Preliminary biological activities of natural and synthesized oxapenam derivatives are listed.

• 公益社団法人日本薬学会の論文
• 1978-06-25

著者

• 平井 功一

  Central Research Laboratories, Sankyo Co., Ltd.

• 平井 功一

  第一三共(株)

• 平井 功一

  Central Research Laboratories Sankyo Co. Ltd.

• 小林 赳夫

  Central Research Laboratories Sankyo Co. Ltd.

• 岩野 雄次

  Central Research Laboratories, Sankyo Co., Ltd.

• 岩野 雄次

  Chemical Research Laboratories:sankyo Co. Ltd.

• 岩野 雄次

  Central Research Laboratories Sankyo Co. Ltd.

関連論文

• Reactivities of 4-Arylthio-2-azetidinones
• Syntheses of 2-Azetidinone (β-Lactam) Ring by Chlorosulfonyl Isocyanate (CSI)
• Chemistry of 2-Substituted Thiothiazoline. V. Reaction of Dianion of 2-Propargylthiothiazoline with Benzaldehyde
• Syntheses and Reactions of 2-Substituted Thiazolidines
• Reactions of β-Keto Sulfide and Sulfoxide with Nitrene and Diazonium Salt
• From Penicillin to Penem and Carbapenem. VII. : Synthesis and Antibacterial Activity of Penem Derivatives
• 第20回国際創薬化学シンポジウム(EFMC-ISMC 2008)報告
• 第6回 AIMECS(AFMC国際医薬化学シンポジウム)(イスタンブール)に出席して
• 不易流行(オピニオン)
• 功労賞受賞 平岡哲夫氏の業績
• 61 ペニシリンからペネム、カルバペネムへ : チエナマイシンの合成
• Synthesis of Oxapenam Derivatives by Silver Induced Cyclization
• Methylthiooxazoline誘導体の反応性〔英文〕
• チアゾリン誘導体を用いる新規合成反応
• Reactions of the 16-Double Bond of 5α, 14β-Androst-16-ene
• A Synthesis of Cephamycins from Cephalosporins and Related Reactions
• A Novel Synthetic Route to 7α-Methoxycephalosporins
• 7α-Methoxylation of Cephalosporins

もっと見る 閉じる

スポンサーリンク