A Novel Synthetic Route to 7α-Methoxycephalosporins
スポンサーリンク
概要
- 論文の詳細を見る
Treatment of 7β-sulfenamidocephalosporins 7 with an oxidizing agent such as active manganese dioxide gave the sulfenimines 8,which were easily methoxylated to the 7α-methoxy-sulfenamides 9 with lithium methoxide. The 7α-methoxy-sulfenamidocephalosporins 9 were converted to the free amine 10 by reaction with sodium iodide. Acylation of 10 afforded the cephamycin derivative 11. This method was also successfully applied to the penicillin series, leading to the sulfenimine 13,which was methoxylated to furnish the desired 6α-methoxy-penicillin 14 together with the ring-opened product 15.
- 公益社団法人日本薬学会の論文
- 1979-11-25
著者
-
平岡 哲夫
New Lead Research Laboratories, Sankyo Co., Ltd.,
-
平岡 哲夫
Central Research Laboratories, Sankyo Co., Ltd.
-
小林 赳夫
Central Research Laboratories Sankyo Co. Ltd.
-
平岡 哲夫
New Lead Research Laboratories Sankyo Co. Ltd.
関連論文
- Synthesis of 2-Deoxy-2-[(2S, 3R)-(2-fluoro-3-hydroxytetradecanoyl)amino]-3-O-[(3R)-3-tetradecanoyloxytetradecanoyl]-D-glucopyranose 4-(Dihydrogen Phosphate) and 2-Deoxy-2-[(2R, 3S)-(2-fluoro-3-hydroxytetradecanoyl)amino]-3-O-[(3R)-3-tetradecanoyloxytetrad
- Studies on Acetylenic Compounds. XLIII. Synthesis of Ibotenic Acid.
- Studies on Acetylenic Compounds. XLIII. Synthesis of Ibotenic Acid
- Synthesis of the Thienamycin Nucleus : A Synthesis of (±)-Diethyl 3-Benzylthio-7-oxo-1-azabicyclo [3. 2. 0] hept-3-ene-2,2-bis (carboxylate)
- Syntheses of 5,5'-Methylenebisisoxazole Derivative and Its Reactions with Electrophiles
- Use of a Shift Reagent in First-Order Analysis of Cyclopropane Derivatives in NMR Spectroscopy
- Reactions of Enamino Ketones and an Enamino Ester with Some Electrophiles
- Synthesis of Oxapenam Derivatives by Silver Induced Cyclization
- Methylthiooxazoline誘導体の反応性〔英文〕
- Studies on Acetylenic Compounds. XLIX. Reactions of Linear-Conjugated Diynones
- Sulfoxonium Ylide Chemistry. III. The Photochemistry of Stable Sulfoxonium Ylides
- Studies on Acetylenic Compounds. XLII. Total Synthesis of Estrone by the Double Cyclization of Acetylenic Compounds
- A Synthesis of Cephamycins from Cephalosporins and Related Reactions
- A Novel Synthetic Route to 7α-Methoxycephalosporins
- 7α-Methoxylation of Cephalosporins
- Reactions of Sulfamides with Thionyl Chloride and a Base
- Reactions of α-Amino Acid Derivatives with Thionyl Chloride. An Application to a Synthesis of 7α-Methoxycephalosporins
- Reactions of Iminophosphoranes of α-Amino Acid Derivatives with Dimethyl Acetylenedicarboxylate. An Application to a Synthesis of 7α-Methoxycephalosporins
- Reactions of Azlactone Derivatives with Nucleophiles and Acetylenic Compounds