Synthesis of 2-Deoxy-2-[(2S, 3R)-(2-fluoro-3-hydroxytetradecanoyl)amino]-3-O-[(3R)-3-tetradecanoyloxytetradecanoyl]-D-glucopyranose 4-(Dihydrogen Phosphate) and 2-Deoxy-2-[(2R, 3S)-(2-fluoro-3-hydroxytetradecanoyl)amino]-3-O-[(3R)-3-tetradecanoyloxytetrad
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概要
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2-Deoxy-2-[(2S, 3R)-(2-fluoro-3-hydroxytetradecanoyl)amino]3-O-[(3R)-3-tetradecanoyloxytetradecanoyl]-D-glucopyranose 4-(dihydrogen phosphate) and 2-deoxy-2-[(2R, 3S)-(2-fluoro-3-hydroxytetradecanoyl)amino]-3-O-[(3R)-3-tetradecanoyloxytetradecanoyl]-D-glucopyranose 4-(dihydrogen phosphate) were synthesized. The (2S, 3R)-compound (9a) was a little more active than GLA-60 in the prostaglandin D_2 releasing test on macrophages, and the(2R, 3S)-compound (9b) was almost inactive.
- 社団法人日本薬学会の論文
- 1992-02-25
著者
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西島 正弘
国立感染研
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汐崎 正生
三共・創薬化学研
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汐崎 正生
東北大学加齢医学研究所 呼吸器腫瘍 研究分野
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荒井 雅巳
三共・活性研
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小林 慶行
New Lead Research Laboratories, Sankyo Co., Ltd.,
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石田 登
New Lead Research Laboratories, Sankyo Co., Ltd.,
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荒井 雅巳
New Lead Research Laboratories, Sankyo Co., Ltd.,
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汐崎 正生
New Lead Research Laboratories, Sankyo Co., Ltd.,
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平岡 哲夫
New Lead Research Laboratories, Sankyo Co., Ltd.,
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西島 正弘
Department of Chemistry, National Institute of Health
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久下 小百合
Department of Chemistry, National Institute of Health
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大塚 俊明
Department of Chemistry, National Institute of Health
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赤松 穰
Department of Chemistry, National Institute of Health
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大塚 俊明
Department Of Chemistry National Institute Of Health
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小林 慶行
三共株式会社化学研究所
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石田 登
New Lead Research Laboratories Sankyo Co. Ltd.
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平岡 哲夫
New Lead Research Laboratories Sankyo Co. Ltd.
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赤松 穰
Department Of Chemistry National Institute Of Health
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久下 小百合
Department Of Chemistry National Institute Of Health
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小林 慶行
New Lead Research Laboratories Sankyo Co. Ltd.
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