Studies on Acetylenic Compounds. LVII. Reactions of 2-Propynyl Sulfones with Cyclic Ketones
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概要
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2-Butynyl phenyl sulfone (VI) and cyclic ketones were treated with sodium hydride to give the corresponding 1 : 1 addition products, respectively. The structures were assigned to 1-phenylsulfonyl-3-(1-cyclohexenyl)2-butanone (VII) and 2-phenylsulfonylmethylene-3-methyloxetane-4-spiro-1'-cyclohexane (VIII) in the case of cyclohexanone and assigned to 1-phenylsulfonyl-3-(1-cyclopentenyl) 2-butanone (XIII) in the case of cyclopentanone, respectively. Acid treatment of VIII afforded three degradation products, VII, X and XI, which confirmed the novel structure of VIII. 2-Propynyl ptolyl sulfone (XIV) and cyclohexanone with sodium hydride treatment gave also an oxetane compound, XV. A plausible mechanism of the reaction and the physical properties of the products were presented in some detail.
- 公益社団法人日本薬学会の論文
- 1971-07-25
著者
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吉本 昌文
Central Research Laboratories, Sankyo Co., Ltd.
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岸田 有吉
Central Research Laboratories Sankyo Co. Ltd.
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石田 登
New Lead Research Laboratories, Sankyo Co., Ltd.,
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石田 登
Central Research Laboratories, Sankyo Co., Ltd.
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石田 登
New Lead Research Laboratories Sankyo Co. Ltd.
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吉本 昌文
Department Of Chemistry Pomona College
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