Studies on Lupin Alkaloids. IV. Total Syntheses of Optically Active Matrine and Allomatrine

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概要

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• Didehydromatrine (III) was reduced to (±)-allomatrinol (VI') and (±)-matrinol (VII'), and the latter of which was converted to N-benzoyl derivative (VIII'). The optical resolution of VI' and VIII' were carried out by means of dibenzoyl-(+)-tartaric acid. N-Benzoyl-(+)-matrinol (VIII) was transformed to (+)-matrinol (VII) via hydrogenolysis. (+)-Matrinol (VII) and (+)-allomatrinol (VI) were derived into (+)-matrine (I) and (+)-allomatrine (V) by oxidation and successive cyclization.

• 公益社団法人日本薬学会の論文
• 1966-03-25

著者

• 奥田 重信

  Institute of Applied Microbiology, University of Tokyo

• 津田 恭介

  共立薬大

• 奥田 重信

  東大応微研

• 奥田 重信

  Institute Of Applied Microbiology The University Of Tokyo

• 津田 恭介

  Institut fur angewandte Mikrobiologie, Universitat Tokio

• 吉本 昌文

  Institut fur angewandte Mikrobiologie der Universitat Tokyo

• 吉本 昌文

  Department Of Chemistry Pomona College

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