Syntheses of Cerulenin and Its Analogs. I. Cerulenin and Its Analogs with Modified Side Chain
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概要
- 論文の詳細を見る
Optically active cerulenin 1,a potent inhibitor of fatty acid synthetase, was prepared via the condensation of the epoxy aldehyde 8 and the alkenyl lithium 16. In order to evaluate the effects of (E, E)-1,4-double bounds of the cerulenin side chain on the interaction with the enzyme, a series of optically active cerulenin analogs 32a-i with modified side chains and tetrahydrocerulenin 3 were synthesized by similar procedures.
- 公益社団法人日本薬学会の論文
- 1992-11-25
著者
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奥田 重信
Institute of Applied Microbiology, University of Tokyo
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森崎 尚子
東大・分生研
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岩崎 成夫
Institute of Molecular and Cellular Biosciences, The University of Tokyo
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嶋澤 るみ子
東大分生研
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岩崎 成夫
Institute Of Applied Microbiology The University Of Tokyo
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古川 淳
(present Address)exploratory Research Laboratories Ii Daiichi Pharmaceutical Co. Ltd.
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森崎 尚子
Institute of Applied Microbiology, The University of Tokyo
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奥田 重信
東大応微研
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奥田 重信
Institute Of Applied Microbiology The University Of Tokyo
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安藤 寿明
Institute Of Applied Microbiology The University Of Tokyo
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嶋澤 るみ子
Institute of Applied Microbiology, The University of Tokyo
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船橋 洋
(Present address)Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.,
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兼松 章
Institute of Applied Microbiology, The University of Tokyo
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船橋 洋
(present Address)tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.
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兼松 章
Institute Of Applied Microbiology The University Of Tokyo
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岩崎 成夫
Institute of Applied Microbiology, The University of Tokyo
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