Syntheses of Cerulenin and Its Analogs. II. Synthesis and Biological Activity of dl-Carbacerulenin, a Carbocyclic Analog of Cerulenin
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概要
- 論文の詳細を見る
2,3-Epoxy-4-hydroxy-4-((E, E)-3,6-octadienyl)cyclopentanone (dl-carbacerulenin 5) was synthesized via the epoxyketones 15a and 15b as a mimic of the active form of the antibiotics cerulenin 1,a potent inhibitor of fatty acid synthetase (FAS). The monobenzyl ethers (12 and 13), synthetic intermediates of 15,were prepared by direct benzylation of the epoxycyclopentene (7). Inhibitory activity of synthesized 5 toward yeast FAS was less than that of cerulenin by a factor of 1000.
- 社団法人日本薬学会の論文
- 1992-11-25
著者
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森崎 尚子
東大・分生研
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川口 昭彦
Department Of Biology College Of Arts And Sciences The University Of Tokyo
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岩崎 成夫
Institute of Molecular and Cellular Biosciences, The University of Tokyo
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嶋澤 るみ子
東大分生研
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岩崎 成夫
Institute Of Applied Microbiology The University Of Tokyo
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森崎 尚子
Institute of Applied Microbiology, The University of Tokyo
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小川 裕司
Institute Of Applied Microbiology The University Of Tokyo
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嶋澤 るみ子
Institute of Applied Microbiology, The University of Tokyo
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船橋 洋
Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.,
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船橋 洋
(Present address)Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.,
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