Epimerization of 6-Protoilluden-8-one at C-3 and the Relative Thermodynamic Stabilities of Stereoisomeric 6-Protoilluden-8-ones
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概要
- 論文の詳細を見る
Both 9-epi-6-protoilluden-8-one (5) and 6-protoilluden-8-one (4) underwent cyclobutylcyclopropylcarbinyl cation rearrangement on treatment with CF_3COOH (25%)-CHCl_3,to give 2,9-cis-2,3-syn 6-protoilluden-8-one (6). In order to elucidate the relative thermodynamic stabilities of these stereoisomeric enones (4-7), molecular mechanical calculations were carried out. The result showed that the cis-syn enone 6 is the most stable one. This is in good agreement with the experimental results.
- 社団法人日本薬学会の論文
- 1985-07-25
著者
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奥田 重信
Institute of Applied Microbiology, University of Tokyo
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岩崎 成夫
東京大学分子細胞生物学研究所
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森崎 尚子
東大・分生研
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野副 重男
Pharmaceutical Institute, Tohoku University
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岩崎 成夫
Institute of Molecular and Cellular Biosciences, The University of Tokyo
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岩崎 成夫
Institute Of Applied Microbiology The University Of Tokyo
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古川 淳
(present Address)exploratory Research Laboratories Ii Daiichi Pharmaceutical Co. Ltd.
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奥田 重信
東大応微研
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板井 昭子
The Department of Pharmaceutical Sciences, The University of Tokyo
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奥田 重信
Institute Of Applied Microbiology The University Of Tokyo
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野副 重男
Pharmaceutical Institute Tohoku University
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板井 昭子
Faculty Of Pharmaceutical Sciences University Of Tokyo
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