Antifungal Properties of Solanum Alkaloids(Biological,Chemical)

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概要

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• The antifungal activities of several solanum alkaloids and their derivatives were examined against a variety of fungal strains such as Candida albicans and Trichophyton spp. Solacongestidine (1) showed the strongest activity (minimum inhibitory concentration) against C. albicans (0.8μg/ml), T. rubrum (0.4μg/ml) and Cryptococcus albidus (0.78μg/ml), and also showed lesser activities against a wide range of fungi. Solafloridine (II) and verazine (VII) showed activities against C. albicans (3.1 and 6.2μg/ml, respectively) and T. rubrunz (25 and 3.1μg/ml, respectively), while other alkaloids such as solasodine (III), tomatidine (IV), tomatillidine (V) and solanocapsine (VI) and related compounds (VIII-XIX) showed much lower activities. Solacongestidine also prolonged the survival time of mice infected with C. albicans.

• 社団法人日本薬学会の論文
• 1987-12-25

著者

• 草野 源次郎

  Osaka University Of Pharmaceutical Sciences

• 草野 源次郎

  Pharmaceutical Institute, Tohoku University

• 高橋 昭

  Faculty Of Pharmaceutical Sciences Tohoku University

• 高橋 昭

  Pharmaceutical Institute, Tohoku University

• 野副 重男

  Pharmaceutical Institute, Tohoku University

• 杉山 和弘

  Pharmaceutical Institute, Tohoku University

• 野副 重男

  東北大薬

• 野副 重男

  Pharmaceutical Institute Tohoku University

• 杉山 和弘

  Pharmaceutical Institute Tohoku University

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