Structure-Activity Relationships in Immunochemistry. III. Inhibition of Complement by Benzyl Pyridinium Ions
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概要
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A quantitative structure-activity relationship for benzyl pyridinium ions inhibiting complement has been formulated. The best equation describing the relationship is log 1/C=0.18π-1+0.46π-2+1.01σ^+-1+0.72D-1+2.50 where C is the molar concentration causing 50% inhibition of complement, π-1 is the hydrophobic constant for substituents on the pyridine moiety and π-2 for substituents on the benzyl moiety, σ^+-1 refers to the electronic effects of substituents on the pyridine ring, and the indicator variable D-1 refers to the SO_2F function in the 2-position of the benzene ring. This expression correlates 69 derivatives with a correlation coefficient of 0.939 and a standard deviation of 0.198. The implications of this relationship for the design of inhibitors is discussed.
- 公益社団法人日本薬学会の論文
- 1975-02-25
著者
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吉本 昌文
Department Of Chemistry Pomona College
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周 玉珠
Department of Chemistry, Pomona College
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周 玉珠
Department Of Chemistry Pomona College
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