Syntheses of 2-Azetidinone (β-Lactam) Ring by Chlorosulfonyl Isocyanate (CSI)
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概要
- 論文の詳細を見る
Attempts were made to prepare sulfur substituted 2-azetidinones by the reaction of vinylsulfide with chlorosulfonyl isocyanate (CSI). The main product of the reaction of β-methylthiostyrene (I) with CSI was pyridone derivative (II), but in the case of 1-phenylthio-1-propene (V) the main products were dihydrouracil derivatives (VI and VII) and acrylic acid derivatives (VIII and IX). Reaction of 1-p-chloro- or p-methylphenylthio-1-propene (Xa and b) with CSI in dry ether at -30°gave the desired 2-azetidinone (β-lactam) derivatives (XIa and b) in 63 and 66.4% isolated yield respectively.
- 公益社団法人日本薬学会の論文
- 1973-05-25
著者
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岸田 有吉
Central Research Laboratories Sankyo Co. Ltd.
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平井 功一
Central Research Laboratories, Sankyo Co., Ltd.
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松田 秀文
Central Research Laboratories, Sankyo Co., Ltd.
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平井 功一
Central Research Laboratories Sankyo Co. Ltd.
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松田 秀文
Central Research Laboratories Sankyo Co. Ltd.
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