Antileukemic Agents. II. New 2,5-Bis (1-aziridinyl)-p-benzoquinone Derivatives

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概要

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• A series of 2,5-bis (1-aziridinyl)-p-benzoquinone derivatives were synthesized and evaluated as antileukemic agents. The most active compounds against lymphoid leukemia L-1210 in BDF_1 mice were 2,5-bis (1-aziridinyl)-3-(2-carbamoyloxyethyl-1-methoxy)-6-methyl-p-benzoquinone, carbazilquinone (7), and related compounds (8,23 and 24). Structure-activity relationships were discussed.

• 社団法人日本薬学会の論文
• 1972-09-25

著者

• 荒川 順生

  Central Research Laboratories Sankyo Co. Ltd.

• 中尾 英雄

  三共株式会社

• 中尾 英雄

  Central Research Laboratories, Sankyo Co., Ltd.

• 中村 隆洋

  Central Research Laboratories, Sankyo Co., Ltd.

• 福島 正美

  Central Research Laboratories, Sankyo Co., Ltd.

• 福島 正美

  Central Research Laboratories Sankyo Co. Ltd.

• 中村 隆洋

  Central Research Laboratories Sankyo Co. Ltd.

• 中尾 英雄

  Central Research Laboratories Sankyo Co. Ltd.

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