Studies on the Total Synthesis of dl-Colchiceine. III.
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概要
- 論文の詳細を見る
dl-Demethoxydeoxy-hexahydrocolchicine (I) was derived to dl-colchiceine (V) by changing the C-ring in (I) to a tropilidene ring (II) and to the tropone compound (III), its amination to form dl-colchiceinamide (IV), and its saponification. Thus, the total synthesis of racemic colchiceine (V) from 1-O-methylpyrogallol was successfully concluded. Partial synthesis of colchiceinamide (IV) from the levorotaory (I) was also carried out.
- 公益社団法人日本薬学会の論文
- 1962-04-25
著者
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中村 隆洋
Central Research Laboratories, Sankyo Co., Ltd.
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中村 隆洋
Takamine Laboratory, Sankyo Co., Ltd.
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中村 隆洋
Central Research Laboratories Sankyo Co. Ltd.
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中村 隆洋
Takamine Laboratory Sankyo Co. Ltd.
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- Studies on the Total Synthesis of dl-Colchiceine. II. Synthesis of dl-Demethoxydeoxyhexahydrocolchiceine.
- Synthesis of Colchicine Synthesis of dl-Demethoxydeoxy-hexahydrocolchicine
- 28 コルヒチンの完全合成
- Studies on the Total Synthesis of dl-Colchiceine. III.
- Studies on the Total Synthesis of dl-Colchiceine. I. Synthesis of 3-Hydroxy-9,10,11-trimethoxy-1,2,3,4,6,7-hexahydro-5H-dibenzo [a, c] cycloheptatrien-5-one.
- Synthesis of Colchicine from Hexahydrodemethoxydeoxycolchicine