Potential Anti-cancer Agents. VIII. Nitration of Pyridazine 1-Oxide. (1).
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概要
- 論文の詳細を見る
Pyridazine 1-oxide (I) was nitrated to 4-nitropyridazine 1-oxide (II) with a mixed acid under a vigorous condition. The structure of II was confirmed as follows. i) Hydrogenation of II itself and methoxypyridazine 1-oxide (VI), derived from II, gave the known 4-aminopyridazine and 4-methoxypyridazine, respectively. ii) Pyridazinol 1-oxide obtained by hydrolysis of VI formed N-methoxypyridazinone with methyl p-toluenesulfonate and sodium methoxide. iii) VI was identical with the compound obtained by hydrogenation of 4-methoxy-3,6-dicholoropyridazine 1-oxide, whose structure was established by its correlation to the known 3,4,6-trimethoxypyridazine 1-oxide. In addition, some reactions related to II were described.
- 公益社団法人日本薬学会の論文
- 1963-01-25
著者
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夏目 幸子
Central Research Laboratories, Sankyo Co., Ltd.
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板井 孝信
Showa College of Pharmaceutical Sciences
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板井 孝信
National Institute of Hygienic Sciences
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夏目 幸子
National Intitute of Hygienic Sciences
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夏目 幸子
Central Research Laboratories Sankyo Co. Ltd.
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