Potential Anticancer Agents. XIII. Reaction of 3,6-Dimethylpyridazine 1-Oxide and Methylpyridazine 1-Oxides with Benzaldehyde.

スポンサーリンク

概要

• 論文の詳細を見る

• The nucleophilic activity of methyl group in 3,6-dimethylpyridazine 1-oxide (I) and monomethylpyridazine 1-oxides (II) with benzaldehyde was studied. Their corresponding (β-hydroxyphenethyl) pyridazine 1-oxides and styryl compounds were gained. From the results, it may be deduced as follows. (i) The reactivity of 3-and 6-methyl groups in I were almost same, different from the cases of 3,6-dichloropyridazine 1-oxide. (ii) 4- and 6-methyl groups in II were similarly reactive, but 5-methyl was more active, and 3-methyl less active than fore-mentioned two methyl groups. These styryl compounds that were produced respectively, were catalytically hydrogenated with Pd-C to corresponding phenethylpyridazine 1-oxides.

• 公益社団法人日本薬学会の論文
• 1963-09-25

著者

• 大草 源三

  Showa College of Pharmaceutical Sciences

• 板井 孝信

  Showa College of Pharmaceutical Sciences

• 板井 孝信

  National Institute of Hygienic Sciences

• 佐子 茂

  National Institute of Hygienic Sciences

• 大草 源三

  National Institute of Hygienic Sciences and Showa Pharmaceutical College

• 佐子 茂

  National Institute Of Hygienic Sciences:(present Address) Ukima Plant Chugai Pharmaceutical Co. Ltd.

関連論文

• The Reaction of Cinnoline 2-Oxides with Phenylmagnesium Bromide
• Studies on Cinnolines. II. On Nitration of Cinnoline 1-Oxide
• On Nitration of Cinnoline 1-Oxide
• ピリダチン誘導体の合成-1-
• パラニトロアニリンに依るP.A.S.中のM.A.P.の比色定量及一齊検査成績について
• Potential Anti-cancer Agents. VI. N-Oxidation of 3-Aminopyridazine Derivatives.
• N-Oxidation of 3-Aminopyridazine Derivatives
• Potential Anti-cancer Agents. I. : Synthesis of Imidazo [4,5-d]-and Triazolo [4,5-d]-pyridazine Derivatives. (1).
• The C-Alkylaminomethylation of Pyridazinol N-Oxides. III. The Mannich Reaction of 5-Pyridazinol 1-Oxide
• The C-Alkylaminomethylation of 3-Pyridazinol 1-Oxide Derivatives. II. The C-Alkylaminomethylation of 6-Substituted 3-Pyridazinol 1-Oxides.
• Synthesis of Pyrazine Derivatives. I. Reactions of 2,5-Dimethylpyrazine N-Oxides with Acid Chlorides
• Autoxidation of Quinoline N-Oxide
• Kinetics of the Nucleophilic Displacement Reactions of Halogenopyridazine 1-Oxides
• Potential Anticancer agents. XIV. Reaction of 3-Substituted Pyridazine 1-Oxide with Benzoyl Nitrate.
• Potential Anti-cancer Agents. XII. Synthesis of 4-Azido-3,6-dimethoxypyridazine Derivatives.
• Potential Anti-cancer Agents. XI. Synthesis of 4- and 5-Azidopyridazine 1-Oxide.
• Potential Anti-cancer Agents. X. Syntheses and Reactions of 3- and 6-Azidopyridazine 1-Oxide.
• Potential Anti-cancer Agents. IX. Nitration of Pyridazine 1-Oxide. (2).
• Potential Anti-cancer Agents. VIII. Nitration of Pyridazine 1-Oxide. (1).
• Potential Anti-Cancer Agents. VII. Azido-purine Derivatives.
• Potential Anti-cancer Agents. IV. 3-Substituted 6-Chloropyridazine 1-Oxides.
• Potential Anti-cancer Agents. V. 3,6-Disubstituted 4-Nitropyridazine 1-Oxides and their Derivatives.
• On the Characterization of 4-Nitropyridazine 1-Oxide and the N-Oxidation of 4-Methoxypyridazines
• Potential Anti-cancer Agents. III. 3,6-Disubstituted 4-Nitropyridazine 1-Oxides.
• Potential Anti-cancer Agents. II. 4-Azidoquinoline and 4-Azidopyridine Derivatives.
• The Reaction of Pyridazine 1-Oxide with Grignard Reagent
• The C-Alkylaminomethylation of Pyridazinol N-Oxides. IV. The Mannich Reaction of 3-and 5-Pyridazinol 1-Oxides using Primary Amines
• 5-Pyridazinol 1-Oxide誘導体の臭素化反応
• The C-Alkyl-aminomethylation of 3-Pyridazinol 1-Oxide Derivatives. I.
• マレイン酸ヒドラジドおよび関連化合物のMannich反応
• Potential Anticancer Agents. XIII. Reaction of 3,6-Dimethylpyridazine 1-Oxide and Methylpyridazine 1-Oxides with Benzaldehyde.
• Syntheses of Pyridazine Derivatives. IV. Halogenopyridazine 1-Oxides
• Syntheses of Pyridazine Derivatives. III. 4-or 5-Chloro-3,6-dimethylpyridazine 1-Oxide.
• Syntheses of Pyridazine Derivatives. II. The Reactivity of Chlorine Atom in 3- or 6-Position of Chloropyridazine 1-Oxide.
• Syntheses of Pyridazine Derivatives. I. The Reactivity of Chlorine Atoms in 3- and 6-Positions of 3,6-Dichloropyridazine 1-Oxide.

もっと見る 閉じる

スポンサーリンク