5-Pyridazinol 1-Oxide誘導体の臭素化反応

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概要

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• Bromination of 5-pyridazinol 1-oxide (VI) under various conditions, 4,6-dibromo-5-pyridazinol 1-oxide (IX) was always produced and the monobromo compound was not obtained. When the 6-position was blocked as in 6-piperidinomethyl-5-pyridazinol 1-oxide (X), 4-bromo-6-piperidinomethyl-5-piridazinol 1-oxide (XI) was obtained in 57% yield. The brominated position was determined by NMR spectroscopy.

• 公益社団法人日本薬学会の論文
• 1968-04-25

著者

• 大草 源三

  Showa College of Pharmaceutical Sciences

• 大草 源三

  昭和薬科大学

• 長田 瑞江

  昭和薬科大学

関連論文

• The Reaction of Cinnoline 2-Oxides with Phenylmagnesium Bromide
• The C-Alkylaminomethylation of Pyridazinol N-Oxides. III. The Mannich Reaction of 5-Pyridazinol 1-Oxide
• The C-Alkylaminomethylation of 3-Pyridazinol 1-Oxide Derivatives. II. The C-Alkylaminomethylation of 6-Substituted 3-Pyridazinol 1-Oxides.
• The Reaction of Pyridazine 1-Oxide with Grignard Reagent
• The C-Alkylaminomethylation of Pyridazinol N-Oxides. IV. The Mannich Reaction of 3-and 5-Pyridazinol 1-Oxides using Primary Amines
• 5-Pyridazinol 1-Oxide誘導体の臭素化反応
• The C-Alkyl-aminomethylation of 3-Pyridazinol 1-Oxide Derivatives. I.
• マレイン酸ヒドラジドおよび関連化合物のMannich反応
• Potential Anticancer Agents. XIII. Reaction of 3,6-Dimethylpyridazine 1-Oxide and Methylpyridazine 1-Oxides with Benzaldehyde.

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