The C-Alkylaminomethylation of 3-Pyridazinol 1-Oxide Derivatives. II. The C-Alkylaminomethylation of 6-Substituted 3-Pyridazinol 1-Oxides.

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概要

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• The Mannich reaction of 6-chloro-and 6-methyl-3-pyridazinol 1-oxide using morpholine or piperidine gave 6-chloro-and 6-methyl-4-alkylaminomethyl-3-pyridazinol 1-oxide. Treatment of 3-pyridazinol 1-oxide with excess amounts of the reagents gave 4,6-di (morpholinomethyl)-3-pyridazinol 1-oxide in 71% yield. These Mannich bases were catalytically hydrogenated to give the corresponding 4-alkylaminomethyl-3(2H)-pyridazinones almost quantitatively.

• 公益社団法人日本薬学会の論文
• 1967-11-25

著者

• 神谷 庄造

  National Institute of Hygienic Sciences, University of Tokyo

• 大草 源三

  Showa College of Pharmaceutical Sciences

• 大草 源三

  Okusa Pharmaceutical Co. Ltd.

• 神谷 庄造

  National Institute Of Hygienic Sciences

• 長田 瑞江

  Showa College of Pharmaceutical Sciences

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