Mutagenic and Prophage-inducing Activities of 1-Alkyl-3-nitrol-nitrosoguanidines
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概要
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A concurrent test for the mutagenicity and the prophage-inducing activity of 1-alkyl-3-nitro-1-nitrosoguanidines (II) was carried out. In mutagenicity test, mutation from streptomycin-dependent to streptomycin-nondependent in E. coli Sd 4 was tested, and in prophage-induction test, induction of lambda-phage in E. coli K12 was used. 1-(2-Chloroethyl)-3-nitro-1-nitrosoguanidine (CNNG) showed the most potent mutagenicity, though the mutagenicity of 1-methyl-3-nitro-1-nitrosoguanidine (MNNG) was remarkably high in comparison with those of other 1-alkyl-3-nitro-1-nitrosoguanidines (II : R=C_<2-9>). While, in prophage-inducing activity, n-propyl (II : R=n-C_3H_7) and n-butyl (II : R=n-C_4H_9) derivatives were most effective, showing larger induction index than MNNG and CNNG. When the alkyl chain became longer than C_5,both activities were extremely weakened.
- 公益社団法人日本薬学会の論文
- 1971-09-25
著者
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神谷 庄造
National Institute of Hygienic Sciences, University of Tokyo
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鈴木 郁生
国立衛生試験所
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鈴木 郁生
National Hygienic Laboratory
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岩原 繁雄
National Institute of Hygienic Sciences
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柳町 きみゑ
National Institute of Hygienic Sciences
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中舘 正弘
National Institute of Hygienic Sciences
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神谷 庄造
National Institute Of Hygienic Sciences
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