Pyridazine 1,2-Dioxide類の研究(第3報)3,6-Dimethylpyridazine 1,2-Dioxideの求核置換反応
スポンサーリンク
概要
- 論文の詳細を見る
3,6-Dimethylpyridazine 1,2-dioxide (I) was reacted with phosphoryl chloride, followed with sodium methoxide, to give 4-chloro-5-methoxy-3,6-dimethylpyridazine (Va), 4,5-dimethoxy-3,6-dimethylpyridazine (VI), 3-methoxymethyl-4-methoxy-6-methylpyridazine (VII), and 3,6-bis(methoxymethyl)pyridazine (VIII). It was presumed that 4,5-dichloro-3,6-dimethylpyridazine (II), 3-chloromethyl-4-chloro-6-methylpyridazine (III), and 3,6-bis(chloromethyl)pyridazine (IV) were produced in the reaction. When the reaction of I carried out with phosphoryl bromide at room temperature, deoxygenation occurred and 3,6-dimethylpyridazine 1-oxide (XII) was obtained preferentially. Treatment of I with acetyl anhydride at 138° for 3 hr gave 3-acetoxymethyl-6-methylpyridazine 1-oxide (XVII) and 3,6-bis(acetoxymethyl)pyridazine (XVIII) in 4% and 2% yields, respectively.
- 公益社団法人日本薬学会の論文
- 1975-11-25
著者
関連論文
- オクテット
- 医薬品の一般名を作るには
- オクテット
- 石館先生を囲んで
- 司薬場から衛生試験所へ : 古文書抜粋
- Synthesis of Antitumor Pyridine and Pyridazine N-Oxides having (2-Chloroethyl) nitrosoureidomethyl and Bis (2-chloroethyl)-aminomethyl Groups
- Antitumor Activity of 4-Nitropyridazine 1-Oxides and Related Compounds for AH-13
- 3,6-Dimethyl-4-nitropyridazine 1-Oxideおよび1,2-Dioxideとナトリウムメトキシドの反応
- Pyridazine 1,2-Dioxide類の研究(第3報)3,6-Dimethylpyridazine 1,2-Dioxideの求核置換反応
- Pyridazine 1,2-Dioxide類の研究(第2報)3,6-Dimethylpyridazine 1,2-Dioxideの求電子反応
- Mutagenic and Prophage-inducing Activities of 1-Alkyl-3-nitrol-nitrosoguanidines
- Studies on Pyridazine 1,2-Dioxides. I. Syntheses of Pyridazine 1,2-Dioxides
- Ring Contraction of 3-Hydroxyquinolines to Oxindoles with Hydrogen Peroxide in Acetic Acid
- Studies on Cinnolines. V. Cinnoline Dioxide.
- Studies on Cinnolines. IV. ON Nitration of Cinnoline 2-Oxide
- Studies on Cinnolines. III. Oxidation of 5-and 8-Nitrocinnoline
- Studies on Cinnolines. II. On Nitration of Cinnoline 1-Oxide
- Studies on Cinnolines. I. N-Oxidation of 4-Chlorocinnoline and 4-Methoxycinnoline.
- On Nitration of Cinnoline 2-Oxide
- On Nitration of Cinnoline 1-Oxide
- 制ガン剤の研究(第15報) : 置換Styrylpyridazine N-Oxide類の合成ならびにその制ガン性について