Antitumor Activity of 3-Nitroso-2-oxazolidones
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概要
- 論文の詳細を見る
2-Oxazolidones (Ia→f) were not effective against rat ascites hepatoma AH13 or mouse lymphoid leukemia, L1210. However, among 3-nitroso-2-oxazolidones (IIa→f), compounds IIa, IIb, IIc and IId were active against AH13,and compounds IIa, IIb and IIf were active against L1210. Cyclic N-nitrosocarbamates and N-nitrosoureas showed greater antitumor effects than the corresponding acyclic N-nitroso compounds. Since the reaction of compounds IIa→f with 4-(p-nitrobenzyl) pyridine gave a purple color, their antitumor mechanism presumably involves alkylation ; but there was no correlation between the antitumor activities and the color intensities.
- 公益社団法人日本薬学会の論文
- 1981-08-25
著者
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宮原 誠
National Institute of Hygienic Sciences, University of Tokyo
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神谷 庄造
National Institute of Hygienic Sciences, University of Tokyo
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宮原 誠
国立医薬品食品衛生研究所 食品部
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宮原 美知子
国立医薬品食品衛生研究所 衛生微生物部
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宮原 誠
National Institute Of Hygienic Sciences
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宮原 美知子
National Institute of Hygienic Sciences
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前川 昭彦
National Institute Of Hygienic Sciences
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神谷 庄造
National Institute Of Hygienic Sciences
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