Quinazolinone誘導体の合成

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概要

• 論文の詳細を見る

• Reaction of 2-ethoxycarbonylamido-5-chlorobenzophenone (II) with benzylamine or 2-piperidinoethylamine respectively afforded 3-benzyl-(III) or 3-(2-piperidinoethyl)-4-hydroxy-4-phenyl-6-chloro-3,4-dihydroquinazolin-2(1H)-one(VI). Unexpectedly, however, reaction of II with aminoalkylamines shown in Chart 1 gave 3-aminoalkyl-4-(aminoalkylamino)-4-phenyl-6-chloro-3,4-dihydroquinazolin-2(1H)-one derivative (V). Heating of II with aminoalcohol or alkylenediamine was found to give a tricyclic quinazolinone derivative. Of the products hereby obtained, oxazolo [3,2-c] quinazoline derivative (VIIIa) was confirmed by synthesis from 3-chloroethyl-4-hydroxy-4-phenyl-6-chloro-3,4-dihydroquinazolin-2 (1H)-one (IX) by a different route.

• 公益社団法人日本薬学会の論文
• 1970-05-25

著者

• 佐藤 裕信

  三共株式会社中央研究所

• 長崎 隆

  Central Research Laboratories, Sankyo Co., Ltd.

• 田中 輝夫

  Central Research Laboratories Sankyo Co. Ltd.

• 田中 輝夫

  三共株式会社中央研究所

• 長崎 隆

  三共株式会社中央研究所

• 長崎 隆

  Central Research Laboratories Sankyo Co. Ltd.

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