9H-Pyrimido[4,5-b]indole誘導体の合成
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概要
- 論文の詳細を見る
The Vilsmeier reaction of 2-benzyloxycarbonylamidoindole (I) afforded 2-benzyloxycarbonylamido-3-formylindole (II) and N-(3-formyl-2-indolyl)-N', N'-dimethylformamidine (III). Various kinds of 3 acylindole derivatives were synthesized by the same reaction. Reaction of II with benzylamine easily effected condensation-cyclization to produce 3-benzyl-2-oxo-2,3-dihydro-9H-pyrimido [4,5-b] indole (VIIa). In order to further extend this reaction, reaction of various 3-acylindole derivatives with various primary amines was carried out and 9H-pyrimido [4,5-b] indole derivatives listed in Tables I and II were synthesized. Benzylation of VIIa gives two kinds of crystals and it was established that these correspond to 3,9-dibenzyl-(XL) and 1,3-dibenzyl-pyrimido [4,5-b] indole derivatives (XLI) from their elemental analytical values, infrared and nuclear magnetic resonance spectra, and their synthesis by a different route.
- 公益社団法人日本薬学会の論文
- 1970-05-25
著者
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佐藤 裕信
三共株式会社中央研究所
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長崎 隆
Central Research Laboratories, Sankyo Co., Ltd.
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田中 輝夫
Central Research Laboratories Sankyo Co. Ltd.
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田中 輝夫
三共株式会社中央研究所
-
長崎 隆
三共株式会社中央研究所
-
長崎 隆
Central Research Laboratories Sankyo Co. Ltd.
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