Synthesis and Biological Activity of Somatostatin Analogues modified at the Tryptophan Residue
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概要
- 論文の詳細を見る
Three analogues of somatostatin, in which the tryptophan residue in position 8 was replaced by 3-(1-naphthyl)-L-alanine, 3-(2-naphthyl)-L-alanine and 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid, were synthesized by the solid-phase method. All of these analogues showed diminished biological activity compared to synthetic somatostatin. The results suggest strongly that the indolyl NH group in the tryptophan residue of somatostatin plays an important role to elicit full hormonal activity and that the function accomplished by the tryptophan residue in somatostatin is different from that in luteinizing hormone-releasing hormone.
- 公益社団法人日本薬学会の論文
- 1978-03-25
著者
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沢野 真二
Department Of Endocrinology Toranomon Hospital Okinaka Memorial Institute For Medical Research Asahi
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馬場 義彦
Central Research Laboratories, Sankyo Co., Ltd.
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矢部 裕一郎
Exploratory Chemistry Research Sankyo Co. Ltd.
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馬場 義彦
Central Research Laboratories Sankyo Co. Ltd
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三浦 千枝子
Central Research Laboratories Sankyo Co. Ltd
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