Analogues of Luteinizing Hormone-Releasing Hormone with Modification in Position 3
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概要
- 論文の詳細を見る
Six analogues of LH-RH, in which the tryptophan residue in position 3 was replaced by nonprotein amino acids, were synthesized and evaluated for their LH-RH activity. The analogues substituted by amino acids having the fused aromatic ring structure in the side-chain retained relatively high biological activity. In particular, the potency of [3- (1-naphthyl)-L-alanine]^3-LH-RH was 187.1% of that of synthetic LH-RH. The results demonstrate that the fused aromatic ring structure of the side-chain in position 3 is a favorable factor, and that the indolyl NH group in the Trp residue is not essential.
- 公益社団法人日本薬学会の論文
- 1976-12-25
著者
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馬場 義彦
Central Research Laboratories, Sankyo Co., Ltd.
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矢部 裕一郎
Central Research Laboratories, Sankyo Co., Ltd.
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三浦 千枝子
Central Research Laboratories, Sankyo Co., Ltd.
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矢部 裕一郎
Exploratory Chemistry Research Sankyo Co. Ltd.
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掘越 大能
Central Research Laboratories, Sankyo Co., Ltd
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掘越 大能
Central Research Laboratories Sankyo Co. Ltd
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馬場 義彦
Central Research Laboratories Sankyo Co. Ltd
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三浦 千枝子
Central Research Laboratories Sankyo Co. Ltd
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