Immunological Cross-Reactivities between Two Yeast Cytochromes c and the Immunological Reactivities of the Peptide Fragments of Saccharomyces oviformis M_2 Cytochrome c

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Cytochromes c from two strains of yeast, Saccharomyces oviformis M_2 (M_2-cyt. c) and Candida krusei, in their cross-reactivities against their antibodies, were investigated by various methods. The results indicated that cytochromes c from these two yeasts cross-reacted each other with their antibodies, but that horse heart cytochrome c did not cross-react. It was also suggested that the passive cutaneous anaphylaxis inhibition test is preferable to the usual in vitro methods in detecting slight difference in the cross-reactivities between closely related antigens. Another experiments using peptide fragments obtained by enzymatic or chemical cleavage of M_2-cyt. c showed that P-4 and P-7 were found to fix complements, and P-3,P-4,P-5 and P-6 eliminated the inhibitory effect of the antibody against the enzymatic reaction of cytochrome c-cytochrome oxidase.
公益社団法人日本薬学会の論文
1973-10-25