Studies on Penem and Carbapenem. II. : An Improved Synthesis of Orally Active Penem Antibiotic (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (5R, 6S)-2-(2-Fluoroethylthio)-6-[(1R)-1-hydroxyethyl]penem-3-carboxylate
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概要
- 論文の詳細を見る
An orally active penem antibiotic (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl(5R, 6S)-2-(fluoroethylthio)-6-[(1R)-1-hydroxyethyl]penem-3-carboxylate (1) was synthesized in 3 steps with a 50% yield from (3S, 4R)-3-[(1R)-1-tertbutyldimethylsilyloxyethyl]-4-[[(2-fluoroethylthio)thiocarbonyl]thio]azetidin-2-one (4) and a new building block, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyloxyoxalyl chloride (3).
- 公益社団法人日本薬学会の論文
- 1990-04-25
著者
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川本 勲
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
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宮内 正雄
Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd.,
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鈴木 こさと
Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd.,
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遠藤 六郎
Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd.,
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遠藤 六郎
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
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宮内 正雄
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
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鈴木 こさと
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
関連論文
- Studies on Seven-membered Ring Compounds. XXXV. Ring Closure of γ-Cycloheptatrienyl-substituted α, β-Unsaturated Carbonyl Compounds to Benzocycloheptene Derivatives
- Studies on Penem and Carbapenem. I. : Syntheses and Oral Absorption of Ester-Type Prodrugs of Sodium (5R, 6S)-2-(2-Fluroethylthio)-6-[(1R)-1-hydroxyethyl]penem-3-carboxylate
- Studies on Orally Active Cephalosporin Esters. II. : Chemical Stability of Pivaloyloxymethyl Esters in Phosphate Buffer Solution
- Studies on Orally Active Cephalosporin Esters. III. : Effect of the 3-Substituent on the Chemical Stability of Pivaloyloxymethyl Esters in Phosphate Buffer Solution
- Studies on Orally Active Cephalosporin Esters. V. : A Prodrug Approach for Oral Delivery of 3-Thiazoliomethyl Cephalosporin
- Studies on Penem and Carbapenem. II. : An Improved Synthesis of Orally Active Penem Antibiotic (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (5R, 6S)-2-(2-Fluoroethylthio)-6-[(1R)-1-hydroxyethyl]penem-3-carboxylate
- Studies on Orally Active Cephalosporin Esters. IV. : Effect of the C-3 Substituent of Cephalosporin on the Gastrointestinal Absorption in Mice