Studies on Seven-membered Ring Compounds. XXX. Rearrangement of Dimethylamino Group in Cycloheptoxazole Derivatives
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概要
- 論文の詳細を見る
Rearrangement of amino group on the seven-membered ring of cycloheptoxazole derivatives was examined. Dimethylamino group in 6-dimethylamino-2-phenyl-6H-cycloheptoxazole (Ia) underwent rearrangement to C-4 and C-8 on standing in a solution, and the ratio of three isomers, Ia, 4-dimethylamino-2-phenyl-4H-cycloheptoxazole (IIa), and 8-dimethylamino-2-phenyl-8H-cycloheptoxazole (IIIa), reached an equilibrium at about 3 : 5 : 2. By the incorporation of dimethylamino-^<15>N into Ia and interchange between the amino group in 6-dimethylamino-2-(2-naphthyl)-6H-cycloheptoxazole (IX), the rearrangement was presumed to take place intermolecularly. 2-(p-Tolyl)-(Ib) and 2-(p-nitrophenyl)-6-dimethylamino-6H-cycloheptoxazole (Ic) also showed similar rearrangement of the dimethylamino group, while the rearrangement was not observed in 2-phenyl-6-(p-toluidino)-6H-cycloheptoxazole (VI) and 5-dimethylamino-5H-benzocycloheptene (VIII).
- 公益社団法人日本薬学会の論文
- 1970-03-25
著者
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相馬 信夫
Central Research Laboratories, Sankyo Co., Ltd.
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中沢 準一
Central Research Laboratories, Sankyo Co., Ltd.
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中沢 準一
Central Research Laboratories Sankyo Co. Ltd.
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杉村 征夫
Central Research Laboratories Sankyo Co. Ltd.
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相馬 信夫
Central Research Laboratories Sankyo Co. Ltd.
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