Studies on the Morphine Alkaloids and Its Related Compounds. XX. Syntheses and Pharmacology of Some Demethylated Compounds Related to the 14-Hydroxy-dihydro-6β-thebainol 4-Methyl Ether (Oxymethebanol), A New Potent Antitussive
スポンサーリンク
概要
- 論文の詳細を見る
Syntheses and Pharmacology of some demethylated compounds related to 14-hydroxy-dihydro-6β-thebainol 4-methyl ether (oxymethebanol), a new potent antitussive, were presented with interest to the structure-antitussive activity relationship on the 6-hydroxyl group in the morphinans. It was suggested that the β (equatorial)-configuration in 6-hydroxyl group is one of essential factors for an appearance of strong antitussive action of the 3,4,6,14-tetrahydroxy-morphinan 3,4-diethers.
- 社団法人日本薬学会の論文
- 1971-01-25
著者
-
高木 弘
Central Research Laboratories Sankyo Co. Ltd.
-
関 功
Central Research Laboratories, Sankyo Co., Ltd.
-
関 功
Central Research Laboratories Sankyo Co. Ltd.
関連論文
- Quantitative Structure-activity Relationships in Minor Tranquilizers Benzodiazepinooxazole Derivatives
- 3,5-Propanopiperidine Derivatives as Potential Analgesics
- Studies on New β-Adrenergic Blocking Agents. II. Syntheses and Pharmacology of 2-Anilinotropone Derivatives
- Studies on New β-Adrenergic Blocking Agents. I. Syntheses and Pharmacology of Coumarin Derivatives
- Studies on the Morphine Alkaloids and Its Related Compounds. XX. Syntheses and Pharmacology of Some Demethylated Compounds Related to the 14-Hydroxy-dihydro-6β-thebainol 4-Methyl Ether (Oxymethebanol), A New Potent Antitussive
- 3-Azabicyclo [3. 3. 1] nonane Derivatives as Potential Analgesics
- Studies on the Morphine Alkaloids and Its Related Compounds. XVIII. Syntheses of N-Substituted-morphinan Dihydronormethines and O-Alkylisoureas related to Morphinan, Norpethidine, or Phenethylamine
- Studies on the Morphine Alkaloids and Its Related Compounds. XVI. Synthesis of 14-Hydroxy-allopseudocodeine 8-Ethers and Its Derivatives
- Untersuchungen auf dem Gebiet der mikrobiologischen Umsetzung. XVI. Umwandlung von Alkaloiden in der Morphin-Reihe durch Trametes sanguinea. (1).
- Gas Chromatography of the Morphine Alkaloids and the Related Compounds
- 強力な新鎮咳薬, 14-Hydroxy-dihydro-6β-thebainol-4-methyl ether (Oxymethebanol)の薬理学的研究
- FEVER RESPONSES TO BACTERIAL PYROGENS IN GUINEA PIGS AND APPLICATION FOR SCREENING OF ANTIPYRETIC AGENTS
- Studies on the Morphine Alkaloids and Its Related Compounds. XIX. The Beckmann Rearrangement of the Oximes of Dihydrothebainones and Its Hofmann Degradation Products
- Studies on the Morphine Alkaloids and Its Related Compounds. XVII. One-Step Preparations of Enol Ether and Pyrrolidinyl Dienamine of Normorphinone Derivatives
- Studies on the Morphine Alkaloids and Its Related Compounds. XV. Isolations of 8β, 14β-Epoxy-codide and 14-Hydroxy-dihydropseudocodeine from Some Nucleophilic Substitution Reaction Products of Tosylate of 14-Hydroxy-codeine or Its Isomers
- Studies on the Morphine Alkaloids and Its Related Compounds. XIV. Preparation of 6-Amino-hydrophenanthrene Compounds from Hofmann Degradation Products of the Morphine Alkaloids.
- Studies on the Morphine alkaloids and Its Related Compounds. XIII. On the Nucleophilic Substitution Reactions of the 14-Hydroxylated Morphine Alkaloids.