Synthesis and Anti-platelet Aggregating Activity of 3-Hetero Analogues of (+)-9(O)-Methano-Δ^<6(9α)>-prostaglandin I_1(Organic,Chemical)

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概要

• 論文の詳細を見る

• Optically active 3-hetero analogues of isocarbacyclin (34a, 38, 39, 40 and 42) as well as ω-chain analogues have been synthesized from the bicyclic alcohol (1). Compound 34d had more potent anti-platelet aggregating activity than prostacyclin in human platelet-rich plasma.

• 社団法人日本薬学会の論文
• 1987-10-25

著者

• 小島 孝一

  Chemical Research Laboratories, Sankyo Co., Ltd.

• 大島 武史

  And Biological Research Laboratories:sankyo Co. Ltd.

• 雨宮 茂雄

  Chemical Research Laboratories Sankyo Co., Ltd.

• 小山 和男

  Chemical Research Laboratories Sankyo Co., Ltd.

• 斉藤 進一

  Chemical Research Laboratories Sankyo Co., Ltd.

• 大島 武史

  Biological Research Laboratories Sankyo Co., Ltd.

• 伊藤 福美

  Biological Research Laboratories Sankyo Co., Ltd.

• 小島 孝一

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

• 斉藤 進一

  Chemical Research Laboratories Sankyo Co. Ltd.

• 雨宮 茂雄

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

• 小山 和男

  Faculty Of Pharmaceutical Sciences Chiba University

• 伊藤 福美

  And Biological Research Laboratories:sankyo Co. Ltd.

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