A Stereoselective Synthesis of a Stable Prostacyclin Analogue : dl-3-Oxa-9(O)-methano-Δ^<6(9α)>-prostaglandin I_1(Organic,Chemical)
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概要
- 論文の詳細を見る
A prostacyclin analogue, dl-3-oxa-9(O)-methano-Δ^<6(9α)>-prostaglandin I_1 (1a), has been synthesized. The key step for this synthesis is a new, one-step conversion reaction of the (hydroxymethyi)cyclopropylketone group in 8 and 21 to the γ,δ-unsaturated ketone 9 and 22, respectively, with iodotrimethylsilane.
- 公益社団法人日本薬学会の論文
- 1987-03-25
著者
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小島 孝一
Chemical Research Laboratories, Sankyo Co., Ltd.
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雨宮 茂雄
Chemical Research Laboratories Sankyo Co., Ltd.
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小山 和男
Chemical Research Laboratories Sankyo Co., Ltd.
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斉藤 進一
Chemical Research Laboratories Sankyo Co., Ltd.
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小島 孝一
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
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斉藤 進一
Chemical Research Laboratories Sankyo Co. Ltd.
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雨宮 茂雄
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
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小山 和男
Faculty Of Pharmaceutical Sciences Chiba University
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