Steroid Series. XXIII. Photolysis of Steroidal 6-Oxygenated 5,19-Lactone (β-Lactone)
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概要
- 論文の詳細を見る
Irradiation of 5,6β-dihydroxy-17β-acetoxy-5β-androstan-19-oic acid 5,19-lactone (I) at room temperature using a mercury arc (450W) was found to yield in 30% yield 5,6β-dihydroxy-17β-acetoxy-5α-androstan-19-oic acid 6,19-lactone (II : R=Ac), structure of which was synthetically established. This photoreaction was proved to proceed through the keto-ketene intermediate (XV) generated upon irradiation of β-lactone moiety in I. On the other hand irradiation of 5-hydroxy-6-oxo-17β-acetoxy-5β-androstan-19-oic acid 5,19-lactone (XIX) afforded 17β-acetoxyestra-5 (10) -en-6-one (XX) in about 60% yield.
- 公益社団法人日本薬学会の論文
- 1970-10-25
著者
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小島 孝一
Central Research Laboratories, Sankyo Co., Ltd.
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林 了三
三共(株)分析代謝研究所
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林 了三
Central Research Laboratories, Sankyo Co., Ltd.
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小島 孝一
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
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田部 勝己
Central Research Laboratories, Sankyo Co., Ltd.
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田部 勝己
Central Research Laboratories Sankyo Co. Ltd.
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