Stereospecific Inversion of Configuration of 2-(2-Isopropylindan-5-yl)-propionic Acid in Rats
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概要
- 論文の詳細を見る
The d-tertiary hydroxy metabolite, which was isolated from rat urine after oral administration of 3,3,3-d_3-l-2-(2-isopropylindan-5-yl) propionic acid (IIPA), was confirmed to retain the intact CD_3 group on the basis of the MS and NMR spectral analyses. This finding is not compatible with the exomethylene intermediate mechanism proposed for the same epimerization reaction of 2-(4-isobutylphenyl) propionic acid (ibuprofen) in human.
- 公益社団法人日本薬学会の論文
- 1980-08-25
著者
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田中 頼久
三共(株)分析代謝研究所
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林 了三
三共(株)分析代謝研究所
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田中 頼久
Central Research Laboratories, Sankyo Co., Ltd.
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林 了三
Central Research Laboratories, Sankyo Co., Ltd.
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