A Convenient Synthesis of (+)-9 (O)-Methanoprostacyclin
スポンサーリンク
概要
- 論文の詳細を見る
(+)-9 (O)-Methanoprostacyclin (1a) and (-)-ent-9 (O)-methanoprostacyclin (1c) were synthesized from the bicyclic esters, methyl (+)-(1S, 2R, 3R, 5R)-3-hydroxy-7,7-ethylenedioxybicyclo-[3.3.0] octane-2-carboxylate (2a) and methyl (-)-(1R, 2S, 3S, 5S)-3-hydroxy-7,7-ethylenedioxybicyclo [3.3.0] octane-2-carboxylate (2b), respectively, which were obtained by optical resolution of the racemic acid (3), followed by esterification. The absolute configurations of 2a and 2b were determined by the chemical correlation method. (+)-9 (O)-Methanoprostacyclin (1a) was found to be as active as prostaglandin E_1,and (-)-ent-9 (O)-methanoprostacyclin (1c) was considerably less active than 1a, in inhibiting platelet aggregation.
- 公益社団法人日本薬学会の論文
- 1985-07-25
著者
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酒井 浄
三共中研
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小山 和男
Chemical Research Laboratories Sankyo Co., Ltd.
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小島 孝一
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
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酒井 浄
Japan And Faculty Of Pharmaceutical Sciences Kyushu University
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雨宮 茂雄
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
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小山 和男
Faculty Of Pharmaceutical Sciences Chiba University
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