25 プロスタグランディンF_<1α>の立体特異的全合成
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概要
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We report a new highly stereospecific total synthesis of PGF_<1α> (1), which proceeds in good to excellent yield at each step. Four asymmetric centers on the cyclopentane ring required for the synthesis of PGF_<1α> was introduced stereospecifically by the catalytic reduction of the enone (6) with palladium on charcoal (6→7: the formation of three asymmetric centers), followec by sodium borohydride reduction (7→8: the formation of additional one asymmetric center).
- 天然有機化合物討論会の論文
- 1972-10-01
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