AFFINITY TO ORGANS, DISTRIBUTION AND IDENTIFICATION OF THIAMINE COMPOUNDS IN ORGANS AFTER ADMINISTRATION OF O-ACETOGLYCOLOYL-S-FUROYLTHIAMINE-35S
スポンサーリンク
概要
- 論文の詳細を見る
1. O-acetoglycolyl-S-furoyl thiamine (AFT)-35S and thiamine (B1)-35S showed obvious differerences in radioactivity in the whole body autoradiogram.2. Administration of AFT-35S exhibited the higher radioactivity in the muscles (heart, skeletal, diaphram, masseter), stomach, brain, brown fat tissue and blood comparing with the case of B1-35S. In these organs, the radioactivity derived from AFT-35S was found at higher concentration and was kept for a longer period as compared with B1-35S.3. AFT converted into thiamine and its phosphoric acid esters within an hour after the administration, and the most abundant derivatives of thiamine was thiamine diphosphate.4. As compared with B1-35S, AFT-35S showed a considerably higher concentration of thiamine diphosphate in various organs.
- 日本ビタミン学会の論文
著者
-
小池 博之
Central Research Laboratories, Sankyo Co., Ltd.
-
中島 栄一
Central Research Laboratories, Sankyo Co., Ltd.
-
水上 明彦
Central Research Laboratories, Sankyo Co., Ltd.
-
長尾 壮七
Department of Radioisotope Laboratories, College of Agriculture and Veterinary Medicine, Nihon University
-
細谷 英夫
Department of Radioisotope Laboratories, College of Agriculture and Veterinary Medicine, Nihon University
関連論文
- Studies on New β-Adrenergic Blocking Agents. II. Syntheses and Pharmacology of 2-Anilinotropone Derivatives
- Studies on New β-Adrenergic Blocking Agents. I. Syntheses and Pharmacology of Coumarin Derivatives
- Studies on the Metabolism of D- and L-Isomers of 3,4-Dihydroxy-phenylalanine (DOPA). IV.^ Urinary and Tissue Metabolites of D- and L-DOPA-^C after Intravenous and Oral Administration to Rats
- Studies on the Metabolism of D- and L-Isomers of 3,4-Dihydroxy-phenylalanine (DOPA). III. Absorption, Distribution and Excretion of D- and L-DOPA-^C in Rats following Intravenous and Oral Administration
- Autoradiographic Studies on the Distribution of Quaternary Ammonium Compounds. IV. Adsorption of Bisonium Ions to Rat Tissues as revealed by in Vitro Whole-body Adsorption Autoradiography
- Autoradiographic Studies on the Distribution of Quaternary Ammonium Compounds. III. Distribution, Excretion and Metabolism of ^C-Labeled Pancuronium Bromide in Rats
- Studies on the Metabolism of D- and L-Isomers of 3,4-Dihydroxyphenylalanine (DOPA). II. Autoradiographic Study on the Distribution of ^C-Labeled D- and L-DOPA after Oral Administration in Rats
- Autoradiographic Studies on the Distribution of Quaternary Ammonium Compounds. II. Distribution of ^14C-Labeled Decamethonium, Hexamethonium and Dimethonium in Mice
- Metabolism of Cloxazolam. I. Distribution, Excretion and Biotransformation in Rats and Mice
- PHARMACOLOGICAL PROPERTIES OF O-ACETOGLYCOLOYL-S-FUROYLTHIAMINE
- Metabolic Fate and Mechanism of Action of Chioroethyithiamine:II. Movement and Fate of Chloroethylthiamine along Intestinal Lumen after Oral Administration to Chick
- AFFINITY TO ORGANS, DISTRIBUTION AND IDENTIFICATION OF THIAMINE COMPOUNDS IN ORGANS AFTER ADMINISTRATION OF O-ACETOGLYCOLOYL-S-FUROYLTHIAMINE-35S