有機化合物の構造活性相関

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Since the discovery of the Quantitative Structure-Activity Relationships (QSAR) by Hansc : h and Fujita in 1963, various methods have been developed and enormous numbers of examples were reported, in order to show their validities.<BR>On the other hand conformational analyses and the receptor fit approach of drugs have been developed during the last decade based on the classical key- lock theory by Fischer and the recent development of computer technology. Another brilliant success in this field is the combination of QSAR, crystallography and molecular graphics by computer.<BR>The time might be coming when the rational research and development of drugs and agriculturals heavily depends on the effective usage of structure-activity relationships and other informations. However drug designers and information people should recognize their roles of prompters to catalyze the efficient research and development.
社団法人有機合成化学協会の論文