Design of New Antidepressants, 4-Anilinopyrimidine Derivatives, Based on Quantitative Structure-Activity Relationships(Medicinal Chemistry,Chemical)
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概要
- 論文の詳細を見る
A quantitative structure-activity relationship formulated for 59 4-anilinopyrimidines inhibiting reserpine-induced ptosis was applied to the design of new, more active, antidepressant compounds. The utility of correlation equations in designing new congeners is discussed and the designed compounds synthesized show the most active group of the anilinopyrimidines.
- 社団法人日本薬学会の論文
- 1987-04-25
著者
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吉本 昌文
Chemical Research Laboratories Sankyo Co. Ltd.
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宮本 秀一
Chemical Research Laboratories, Sankyo Co., Ltd.
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渡辺 英俊
Chemical Research Laboratories, Sankyo Co., Ltd.
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上岡 利春
Biological Research Laboratories, Sankyo Co., Ltd.
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中山 勲
Biological Research Laboratories, Sankyo Co., Ltd.
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古林 隆司
Ube Laboratory, Corporate Research and Development, Ube Industries, Ltd.
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本田 建夫
Ube Laboratory, Corporate Research and Development, Ube Industries, Ltd.
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渡辺 英俊
Chemical Research Laboratories Sankyo Co. Ltd.
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本田 建夫
Ube Laboratory Corporate Research And Development Ube Industries Ltd.
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中山 勲
Biological Research Laboratories Sankyo Co. Ltd.
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上岡 利春
Biological Research Laboratories Sankyo Co. Ltd.
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宮本 秀一
Chemical Research Laboratories Sankyo Co. Ltd.
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古林 隆司
Ube Laboratory Corporate Research And Development Ube Industries Ltd.
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