Synthesis of N^6- or 8-Substituted 9-(β-D-Arabinofuranosyl)-adenines and Their Antiviral Activities against Herpes Simplex and Vaccinia Viruses
スポンサーリンク
概要
- 論文の詳細を見る
9-(β-D-Arabinofuranosyl) adenine (Ara-A) was synthesized from adenosine 5'-monophosphate in 30% yield via 8,2'-O-cycloadenosine as an intermediate. Various 8-substitutedamino Ara-A derivatives were obtained by aminolysis of 8,2'-O-cycloadenosine and N^6-substituted Ara-A derivatives were also obtained by reaction of 6-chloro-9-(β-D-arabinofuranosyl) purine with amines. In vitro antiviral activities of the N^6- or 8-substituted Ara-A were determined by the degree of cytopathic effect inhibition.
- 公益社団法人日本薬学会の論文
- 1977-10-25
著者
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清水 文治
Central Research Laboratories of Sankyo Co., Ltd.
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金子 正勝
Central Research Laboratories of Sankyo Co., Ltd.
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木村 美佐子
Central Research Laboratories of Sankyo Co., Ltd.
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西村 卓三
Central Research Laboratories Sankyo Co., Ltd.
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木村 美佐子
Chemical Research Laboratories:sankyo Company Ltd.
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西村 卓三
Central Research Laboratories Sankyo Co. Ltd.
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