Studies on Griseolic Acid Derivatives. IV. : Synthesis and Phosphodiesterase Inhibitory Activity of Acylated Derivatives of Griseolic Acid(Organic,Chemical)
スポンサーリンク
概要
- 論文の詳細を見る
Mono-, di- or triacylated griseolic acid derivatives were synthesized by selective acylation or by selective hydrolysis of the polyacylated derivatives. The inhibitory activities of these compounds against adenosine 3',5'-cyclic monophosphate or guanosine 3',5'-cyclic monophosphate phosphodiesterase were investigated to clarify the structure activity relationship. Acylation of the amino group of the adenine moiety greatly reduced the inhibitory activity. On the other hand, acylation of the hydroxy groups at the 7'- and 2'-position had relatively little effect on the inhibitory activity.
- 公益社団法人日本薬学会の論文
- 1987-03-25
著者
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室伏 良信
Chemical Research Laboratories:sankyo Company Ltd.
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山崎 光郎
Biological Research Laboratories, Sankyo Co., Ltd.
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木村 美佐子
Chemical Research Laboratories:sankyo Company Ltd.
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飯島 康輝
Biological Research Laboratories
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金子 正勝
Chemical Research Laboratories
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飯島 康輝
Biological Research Laboratories:sankyo Co. Ltd.
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